Cu(I) Mediated Azidation of Halobenzenes, and Cu Catalysed Selective Azide Reduction to Corresponding Amines

Abstract Aryl amines are synthesized from halobenzenes via copper mediated reactions employing sodium azide under mild conditions in ethanol/water. The reaction proceeds stepwise the aryl azide, which is reduced to corresponding amine in‐situ . methodology allows syntheses of para ‐, meta ‐ and ortho ‐bromobenzenes bearing electron withdrawing groups. Bifunctional alkanoyl chains with terminal bromides selectively transformed, generating an aniline aliphatic as this position stable reduction. A one‐pot multistep sequence for preparation target was designed. formation by Cu I while elemental generated simultaneously, deposited onto employed PTFE stirring bar used reaction. films were quantified analysed SEM/EDS. Cu, either or solution, responsible reduction, possibly involving nitrene intermediates. An application modified bars a heterogeneous catalyst click demonstrated. magnified image